The expression and clinical significance of augmenter of liver regeneration in patients with HBV related acute on chronic liver failure
10.3969/j.issn.1671-8348.2014.20.013
- VernacularTitle:肝再生增强因子在 HBV 相关慢加急性肝功能衰竭中的水平变化及意义
- Author:
Chun YANG
;
Wen CHEN
;
Cunliang DENG
;
Yiliang BI
;
Li TANG
;
Gang WU
- Publication Type:Journal Article
- Keywords:
augmenter of liver regeneration;
hepatitis B virus;
acute on chronic liver failure;
expression
- From:
Chongqing Medicine
2014;(20):2579-2581
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of augmenter of liver regeneration (ALR) in patients with HBV related acute on chronic liver failure (ACLF) .Methods The serum and clinical data of patients with ACLF (ACLF group ,n=214) ,patients with mild chronic hepatitis B (mild chronic hepatitis B group ,n=196) were collected from outpatient and inpatient in the hospital ,and control group(n=200) people were the blood transfusion healthy blood donors .The level of ALR was measured by ELISA method .The correlation between ALR and MELD score of patients with ACLF were analyzed by linear regres-sion analysis .Unconditioned binary response logistic regression model was used to determine the correlation between ALR and mor-tality at 24 weeks of patients with ACLF .Results Serum ALR level was higher in ACLF group than in mild chronic hepatitis B group and control group(P<0 .05) .There were negative correlations between the serum ALR level and MELD score of patients with ACLF(r2 = -0 .249 ,F=13 .955 ,P<0 .01) .Serum ALR level of patients with ACLF was more significant in survival group than in dead group(P=0 .004) .Logistic regression analysis identified that high serum ALR level was related to the good prognosis (P=0 .012 ,OR=0 .807) .Conclusion The serum ALR level was significantly increased in patients with HBV related ACLF which played an important role in liver regeneration and improve the prognosis of patients .
