Stady on the clinical characteristics of 10 patients with idiopathic cytopenia of undetermined significance

VernacularTitle:10例意义未明特发性血细胞减少症的临床特征研究
Author: Jie PU ; Jun SHI ; Zhen CHEN ; Daopei LU ; Quan PU
Publication Type:Journal Article
Keywords: myelodysplastic syndrome; meaning unclear idiopathic cytopenia disease; minimum standards; karyotype
From: Chongqing Medicine 2014;(21):2698-2700
CountryChina
Language:Chinese
Abstract: Objective To analyze the clinical and pathologic features in patients with ldiopathic cytopenia of undetermined signif-icance (ICUS) ,and provide the diagnostic basis .Methods 10 ICUS patients who did not fulfil minimal diagnostic criteria for MDS but suffered from constant (>6 months) progressive cytopenia ,with no marked dysplasia (<10% in three-major cell lineages) and abnormal karyotype were reported .Results 2 of 10 patients transited to MDS ,bone marrow review showed that ≥2 cells appeared diagnostic pathology development .Karyotype analysis showed that 1 case was still normal ,1 case lost a normal chromosome 20 (20q-) ,the rest 8 cases had been efollowed up for 6 to 25 months and still maintain ICUS .Conclusion Patients with MDS who fail to meet the diagnostic criteria of ICUS ,must carry out regular follow-up .There are some patients can transition to public MDS after a certain incubation period ,in fact it is Pre-MDS or MDS-early before ,which shows that ICUS should cause clinical attention ,so that avoid missed diagnosis .