Meta-analysis of studies on inhaled corticosteroids and montelukast in children with asthma

VernacularTitle:吸入性糖皮质激素与孟鲁司特治疗儿童哮喘疗效的M eta分析
Author: Mei GUO ; Zhou FU
Publication Type:Journal Article
Keywords: children with acute asthma; inhaled corticosteroids; montelukast
From: Chongqing Medicine 2014;(21):2730-2733
CountryChina
Language:Chinese
Abstract: Objective To compare the effect of inhaled corticosteroids and montelukast in children with asthma .Methods Data were obtained from Pubmed ,Embase and Central databases ,CNKI and VIP .Only randomized controlled trials (RCT ) that evalua-ting inhaled corticosteroids and montelukast for children were included .The Cochrane collaboration risk bias tools was used to eval-uated the quality of literature .Results The patients with inhaled corticosteroids had a better effect in FEV 1% and PEF than pa-tients with montelukast ,the incidences of adverse drug reactions had no statistically significant difference .The patients with inhaled corticosteroids combined with montelukast had a better effect in FEV 1% or PEF than patients with inhaled corticosteroids only . Conclusion The effect of inhaled corticosteroids is better than montelukast ,the effect of inhaled corticosteroids combined with montelukast is better than inhaled corticosteroids only ,and has drug safety .