The association between Fas-670 gene polymorphisms and clinic pathologic index of breast cancer in Qinghai district

VernacularTitle:F as-670基因多态性与青海地区乳腺癌临床病理指标间的关系
Author: Xin HUANG ; Xiujuan WANG ; Liyan JIN ; Shuangyuan ZHANG
Publication Type:Journal Article
Keywords: breast neoplasms; Fas-670; gene polymorphisms; clinic pathologic index
From: Chongqing Medicine 2014;(20):2617-2619
CountryChina
Language:Chinese
Abstract: Objective To investigate the correlation between Fas-670 gene polymorphisms and the clinic pathologic index of breast cancer in Qinghai district .Methods The polymorphisms of Fas-670 gene were detected by polymerase chain reaction-restric-tion fragment length polymorphisms assay (PCR-RFLP) in 232 female breast cancer patients ,χ2 test was applied to assess the asso-ciation between the polymorphisms of Fas-670 gene and breast cancer clinic pathologic index .Results In 232 breast cancer pa-tients ,the frequency of Fas-670 homozygous wild type(AA) ,heterozygous type(AG) ,homozygous mutant type(GG) were 39 .7%(92/232) ,48 .7% (113/232) ,11 .6% (27/232) respectively .It was no statistical significance between Fas-670 gene polymorphisms and the clinic pathologic index of breast cancer in Qinghai district(P>0 .05) .Conclusion The polymorphisms of Fas-670 gene is not associated with clinic pathologic index of breast cancer in Qinghai district .