Effect of Topiramate on Risperidone-Induced Weight Gain: A Pilot Study.
- Author:
Moon Yong CHUNG
1
;
Eun Mi CHEON
;
Ji Young JUNG
;
Tae Young LEE
Author Information
1. Department of Neuropsychiatry, Seoul Veterans Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Risperidone;
Topiramate;
Schizophrenia;
Weight gain
- MeSH:
Body Mass Index;
Body Weight;
Diarrhea;
Fatigue;
Humans;
Paresthesia;
Pilot Projects*;
Risperidone;
Schizophrenia;
Weight Gain*
- From:Korean Journal of Psychopharmacology
2005;16(6):468-474
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: It is known that risperidone induces weight gain moderately which has been previously considered of little clinical concern. And there was no specific effective treatment for atypical antipsychotics-induced weight gain. The study was performed to evaluate the effectiveness of topiramate as an weight-reducing medicine for schizophrenia patients with risperidone-induced weight gain. METHODS: Topiramate, 100-200 mg/day, was administered to 12 schizophrenia patients with risperidone-induced weight gain. Body weight and body mass index (BMI) were measured at baseline, 4-week and 8-week. Brief Psychatric Rating Scale (BPRS) and Positive And Negative Syndrome Scale (PANSS) were used to evaluate psychotic symptoms. RESULTS: Body weight and BMI were decreased significantly at 4-week and 8-week treatment compared to baseline (weight loss: 1.17+/-1.80 kg and 2.50+/-2.24 kg; BMI: -0.41+/-0.65 kg/m2 and -0.88+/-0.82 kg/m2 on 4-week and 8-week). Psychiatric symptoms were improved significantly in BPRS and PANSS. Adverse effects were showed such as fatigue, paresthesia, difficulty in concentration and diarrhea, which were mild and self-limited. CONCLUSION: It is suggested that topiramate have significant effects on patients with risperidone-induced weight gain. Randomized controlled study would be necessary in the near future.
