The evalue of procalcitonin detection in guiding antibiotic use
10.3969/j.issn.1673-4130.2014.14.023
- VernacularTitle:血清降钙素原测定在指导抗菌药物应用中的价值
- Author:
Yongqian YAN
- Publication Type:Journal Article
- Keywords:
procalcitonin;
antibiotic application;
bacterial infectious diseases
- From:
International Journal of Laboratory Medicine
2014;(14):1870-1872
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of the procalcitonin (PCT)measurement in preventing the occurrence of the bacterial drug resistance and reducing the overuse of antibiotics.Methods 400 inpatients without thyroid dysfunction but with suspected bacterial infections in our hospital from June 2012 to April 2013 were screeded out.Under the patient′s informed consent and the allowable condition,the routine treatment group (200 cases )and the PCT guidance group(200 cases )were obtained. Then,the antibiotic use time,hospitalization duration and hospitalization expenses were retrospectively anlyzed in the two groups. Meanwhile,the PCT guidance group was dynamically monitored.Results The mean antibiotic therapeutic time in the PCT guidance group was shorter than that in the routine treatment group;the average hospitalization days had statistical difference between the two groups (P<0.001 );the antibiotic expenses accounted for 26.4% and 32.0% of the hospitalization medication costs,which also had statistically significant difference (P <0.001).The clinical pulmonary infection scores(CPIS)were not compared because of lacking microbiology indicators.During the dynamic monitoring,when PCT<0.10 ng/mL,the antibiotic use was stopped,when PCT≥0.25 ng/mL,the antibiotic use was restored,when PCT≥0.25 ng/mL or≥0.50 ng/mL for consecutive 3 d,adjusting the antibiotics,dose or administrating route obtained significantly therapeutic effect,which indicating that PCT could be used for the prognosis judgement of the disease.Conclusion The once measurement of serum PCT could guide for diagnosing and assessing the infection degree,while its continuous measurement could guide the antibiotic use and make the prognosis on the disease condition.
