Investigation on drug resistance status quo of imipenem-resistant Pseudomonas aeruginosa in Xi′an area and carbapenemase genes
10.3969/j.issn.1673-4130.2014.14.028
- VernacularTitle:西安地区耐亚胺培南铜绿假单胞菌耐药现状及碳青霉烯酶基因研究
- Author:
Lijuan WANG
;
Wuping LI
;
Xiuli XU
- Publication Type:Journal Article
- Keywords:
imipenem-resistant Pseudomonas aeruginosa;
drug resistance;
carbapenemase genes
- From:
International Journal of Laboratory Medicine
2014;(14):1882-1884
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the drug resistance status quo of imipenem-resistant Pseudomonas aeruginosa and carbap-enemase gene carrying in Xi′an area for guiding the clinical rational use of antibacterial drugs.Methods 151 strains of imipenem-re-sistant Pseudomonas aeruginosa isolated from clinical samples in 4 hospitals from August 2012 to July 2013 were continuously col-lected.Then the drug resistance characteristics of imipenem-resistant Pseudomonas aeruginosa were investigated by the antimicrobi-al drug sensitivity test.The PCR technique was adopted to detect the carrying situation of carbapenemase drug-resistance genes in imipenem-resistant Pseudomonas aeruginosa.Results Totally isolated 151 strains of imipenem-resistant Pseudomonas aeruginosa were mainly distributed in the neurosurgery ICU (37.1%),neurology ICU (27.1%)and the burn department (19.9%);the detec-ted strains were sensitive to polymyxin B and resistant to other 9 kinds of antibacterial drugs in different degrees;94 strains carried VIM gene,32 strains carried IMP gene,5 strains carried SPM gene and 3 strains carried SIM gene.Conclusion The multidrug re-sistance and pan-drug resistance phenomenon of imipenem-resistant Pseudomonas aeruginosa is serious,its cause might be related with the carbapenemases-producing drug resistant gene expression,the drug resistance genes are dominated by VIM and IMP.Clinic should strengthen the bacterial drug resistance monitoring and use antibacterial drugs rationally and effectively for preventing the spreading of imipenem-resistant Pseudomonas aeruginosa.
