Diagnostic value of soluble transferrin receptor detection in non-adult ion deficiency anemia
10.3969/j.issn.1673-4130.2014.14.029
- VernacularTitle:可溶性转铁蛋白受体检测对非成年人缺铁性贫血的诊断价值
- Author:
Yulian JIANG
;
Liya MO
;
Cong ZHANG
;
Bibo QIU
- Publication Type:Journal Article
- Keywords:
non-adult;
transferring receptor;
diagnosis;
iron deficiency anemia;
anemia of chronic disease
- From:
International Journal of Laboratory Medicine
2014;(14):1885-1886
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of the soluble transferrin receptor (sTfR)in non-adult iron deficiency anemia (IDA)and its differential diagnostic value between IDA and anemia of chronic disease(ACD).Methods 26 cases in the IDA group involved 12 males and 14 females,aged 1 month to 15.5 years;33 cases in the ACD group involved 17 males and 16 females, aged 2 months to 14.0 years;30 cases in the normal control group involved 15 males and 15 females,aged 1 month to 15.5 years. Serum sTfR and ferritin (SF)were detected by the immunonehelomitery,serum iron (SI)was detected by Ferrous Oxazine colori-metric method.Results The gender and age had no statistically significant difference among 3 groups;the SI mean value in the ACD group located between the IDA group′s and the normal control group′s;the SF mean value of the IDA group was significantly lower than that of ACD group (P <0.001)and that of control group (P <0.001),while the sTfR mean value of IDA group was significantly higher than that of the ACD group (P <0.001)and that of the normal control group (P <0.001).The best cutoff of sTfR for the differential diagnosis between IDA and ACD was 3.56 mg/L,its sensitivity,specificity,negative predictive value,posi-tive predictive value and accuracy were 95.12%,93.92%,94.11%,97.53% and 95.50% respectively.Conclusion sTfR has higher sensitivity and specificity for IDA and is conducive to diagnose IDA and differentially diagnose ACD.
