Correlation of HBV-DNA load,ALT and TBA levels with hepatitis B virus infection pattern
10.3969/j.issn.1673-4130.2014.14.046
- VernacularTitle:HBV-DNA 和 ALT、TBA 水平与 HBV 感染模式的相关性研究
- Author:
Hui LIN
;
Sumei PENG
;
Zhenjie CHEN
- Publication Type:Journal Article
- Keywords:
hepatitis B virus;
alanine transaminase;
total bileacid
- From:
International Journal of Laboratory Medicine
2014;(14):1925-1927
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation of serum HBV-DNA load,transaminase(ALT)and total bile acid (TBA)levels with hepatitis B virus (HBV)infection patterns to assess HBV infectivity.Methods The fluorescent quantitative PCR was used to detect serum HBV-DNA in 308 patients with HBV infection.ELISA was adopted to detect the HBV markers.The continuous mo-nitoring method was adopted to detect serum ALT and the cycling enzymatic method was adopted to detect serum TBA.Results The HBV-DNA content and serum ALT level had staitstical differences among the 3 infection patterns of HBsAb,HBeAg and HB-cAb positive,HBsAg,HBsAb,and HBcAb positive and 1,5 positive (P <0.05),the partial patients with HBeAg negative had the active HBV replication in vivo;HBV-DNA copy number in the patients with HBeAg negative was positively correlated with ALT level (P <0.05).Serum TBA level had no statistical difference among three knds of HBV infection patterns (P >0.05).Conclusion Serum HBV-DNA content and ALT activity have the correlation with the different HBV infection patterns,which could reflect the HBV replication and the infectivity intensity in some extent.
