Effect of irbesartan and nifedipine controlled-release tablets on morning blood pressure surge
10.3969/j.issn.1006-5725.2014.13.046
- VernacularTitle:厄贝沙坦与硝苯地平控释片降低血压晨峰的作用对比
- Author:
Zhaoxia ZHOU
;
Shunda WANG
;
Dong WU
- Publication Type:Journal Article
- Keywords:
Hypertension;
Mean artery pressure;
Morning blood pressure surge;
rbesartan;
Nifed-ipine controlled-release tablets
- From:
The Journal of Practical Medicine
2014;(13):2151-2153
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of irbesartan and nifedipine controlled-release tablets on morning blood pressure surge in patients with essential hypertension. Methods Ninety patients with essential hypertension were randomly divided into irbesartan group ( group A, n = 45) and nifedipine group (group B, n =45). Irbesartan tablets 150 mg/d and nifedipine controlled-release tablets 30 mg/d were respectively given in group A and group B for 4 weeks. The levels of diastolic blood pressure (DBP), systolic blood pressure (SBP), mean arterial pressure ( MAP ) and morning blood pressure surge ( MBPS ) before and after treatment were measured by ambulatory blood pressure monitoring. Results The DBP, SBP, MAP and MBPS levels of two groups after treatment for 4 weeks were all decreased (P < 0.01). All the indexes of group B decreased more significant compared to group A (P < 0.05 ). Conclusion To control blood pressure and prevent morning blood pressure surge, nifedipine controlled-release tablets are better than irbesartan.
