Age-related degeneration of auditory function and the expression of NGFR TrkA in the cochlea of senescence-accelerated mouse
10.3969/j.issn.1006-5725.2014.13.007
- VernacularTitle:快速老化小鼠听功能及耳蜗组织神经生长因子受体酪氨酸激酶受体A的增龄性变化
- Author:
Xiang WANG
;
Qianghe LIU
;
Jie WANG
- Publication Type:Journal Article
- Keywords:
Hearing;
Senescence accelerated mouse;
Threshold of auditory brainstem response;
Cochlea;
TrkA
- From:
The Journal of Practical Medicine
2014;(13):2038-2041
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore hearing loss , the expression of age-related changes of nerve growth factor receptor TrkA (NGFR TrkA ) in the cochlea of the senescence-accelerated mouse. Methods The senescence accelerated mouse/prone 8(SAMP8) at 3, 5, 7 months were chosen as analyzing subjects. The auditory thresholds was monitored by auditory brainstem respons (ABR). The expression of NGFR TrkA protein was analyzed by the optical density of immunohistochemical staining. Results The SAMP8 developed a progressive auditory threshold which showed an age-related significant increase (P < 0.05). There were NGFR TrkA protein expressed in the cochlea of the SAMP8 throughout the development, which developed an age-related significant descend (P<0.05). Conclusion The expression level of NGFR TrkA protein decreases when the SAMP 8 develops a progressive hearing loss which indicates that NGFR TrkA protein probably has relationship with maintaining functional status of the cochlea.
