Correlation between the hypoxia inducible factor-1αPro582Ser polymorphism and type 2 diabetic nephropathy

VernacularTitle:缺氧诱导因子1αPro582Ser基因多态性与2型糖尿病肾病相关性研究
Author: Qin ZHANG ; Yaxin BI ; Guoxi JIN ; Yan ZHANG
Publication Type:Journal Article
Keywords: Diabetic nephropathy; Hypoxia-inducible factor-1α; Polymorphism
From: The Journal of Practical Medicine 2014;(13):2078-2080
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship between the hypoxia-inducible factor-1α (HIF-1α) Pro582Ser polymorphism and type 2 diabetic nephropathy (DN). Methods Two hundred and forty four subjects with type 2 diabetes were recruited. HIF-1α Pro582Ser polymorphism was detected using PCR-RFLP to analyses. Results SNPs were detected at the site of 1 285 bp of HIF-1α exon , which could turn proline to serine (Pro582Ser). T allele carrying rate was significantly higher in the patients with DN than in those with right diabetes (P<0.05) at 1 285 bp site of HIF-1αexon. By Logistic regression analysis, high HbA1c and low HDL-c were risk factors for DN and Pro582Ser was excluded in the equation. Conclusion High HbA1c and low HDL-c are risk factors for type 2 DN. HIF-1αPro582Ser SNPs may be correlated with type 2 DN, but the correlation needs further exploration.