Effect of EGB on SOD, MDA of ventilator-induced lung injury in rats

VernacularTitle:银杏叶提取物对大鼠机械通气所致肺损伤SOD、MDA的影响
Author: Yue ZHUANG ; Qi ZHANG ; Wenxiang JIN
Publication Type:Journal Article
Keywords: Extract of Ginkgo biloba; Ventilator-induced lung injury; Superoxide dismutase; Malonaldehyde
From: The Journal of Practical Medicine 2014;(12):1864-1866
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of EGB on SOD, MDA of ventilator-induced lung injury in rats and its possible mechanisms. Methods Thirty male SD rats were randomly divided into 3 groups: control group (C group), high tidal ventilation group (H group) and EGB group (E group). The setting mechanical ventilation was VT=30 mL/kg, RR=40/min, I/E=1/3, PEEP=0 cmH2 O and FiO2=21%. The broncho-alveolar lavage fluid (BLAF) and serum were obtained for determination of the levels of SOD and MDA at the end of 4 h mechanical ventilation. The Lungs were removed, and the wet-to-dry weight ratio (W/D) and pulmonary pathologic changes were measured. Results As compared with C group, W/D and the levels of MDA were significantly increased in H group, but the levels of SOD were reduced in H group. As compared with H group, W/D and the levels of MDA were significantly decreased in E group, but the levels of SOD were increased in E group. Pulmonary pathologic changes were alleviated in E group comparing with H group. Conclusion EGB injection may have a protective role against hyperoxia and induced pulmonary damage in rats.