Diagnostic utility of hemoglobin electrophoresis in neonatal cord blood screening for thalassemia
10.3969/j.issn.1006-5725.2014.12.031
- VernacularTitle:脐血血红蛋白电泳在新生儿地中海贫血筛查中的应用
- Author:
Hao GUO
;
Li DU
;
Bin TANG
;
Mingyong LUO
;
Danqing QIN
;
Yixia WANG
- Publication Type:Journal Article
- Keywords:
Thalassemia;
Hemoglobin electrophoresis;
Neonatal screening;
Cord blood
- From:
The Journal of Practical Medicine
2014;(12):1953-1955
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the diagnostic utility of hemoglobin electrophoresis in neonatal cord blood screening for thalassemia. Methods Between January 2012 and December 2013, 14032 core blood samples which were from different 21 Women and Children Hospitals in Guangdong were performed for the neonatal screening with hemoglobin electrophoresis. The positive samples of hemoglobin electrophoresis were recalled for genetic testing. Results Out of 1445 (11.07%) positive samples of hemoglobin electrophoresis , 1075 (54.08%) cases were suspected for α-thalassemia, 478 (3.41%) cases were suspected for β-thalassemia, 127 (0.91%) cases were suspected for abnormal hemoglobin. With the genetic testing, 967 cases were diagnosed as α-thalassemia, 404 cases were diagnosed asβ-thalassemia. The coincidence rate ofα-thalassemia andβ-thalassemia were 89.95%and 82.96%, respectively. Besides, 124 cases were diagnosed as abnormal hemoglobin, including 38 cases of Hb E, 28 cases of Hb Q, 21 cases of Hb D, 19 cases of Hb New York, 13 cases of Hb J, and 5 cases of Hb J. Conclusion Hemoglobin electrophoresis was definitely helpful in the neonatal cord blood screening for thalassemia and abnormal hemoglobin.
