Distribution and clinical significance of genotypes and subtypes of hepatitis B virus in HBV-infected patients
10.3969/j.issn.1006-5725.2014.12.032
- VernacularTitle:合肥地区不同类型乙型肝炎病毒感染者病毒基因型和基因亚型分布及其临床意义
- Author:
Sufang XU
;
Yuanhong XU
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Genotype;
Subtypes;
Polymerase chain reaction
- From:
The Journal of Practical Medicine
2014;(12):1955-1958
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the distribution and its clinical significance of hepatitis B virus genotypes and subtypes in HBV-infected patients in Hefei. Methods 192 serum samples from HBV-infected patients were collected to extract HBV DNA. HBV the genotypes and subtypes of HBV were detected by PCR. Results Among 192 HBV-infected patients, 82 had genotype B, 99 had genotype C, and 11 had B/C. In genotype B, 57 were subtype Ba, 8 were subtype Bj, and the remaining 17 were neither Ba nor Bj. In genotype C, 8 were subtype C1, 56 were subtype C2, and the other 35 were neither C1 nor C2. In genotype B/C, 6 were Ba/C2, 2 Bj/C2, 2 Ba/neither C1 nor C2, and one neither Ba nor Bj/C2. Tthe distribution of HBV genotypes and subtypes exhibited significant differences in the various clinical types; and it showed that genotype C was predominant among patients with liver cirrhosis and hepatocellular carcinoma , while genotype B was predominant in asymptomatic carriers. In addition, there were no differences in HBV genotype distribution among patient wih different gender; but the genotype distribution differed significantly between patients positive with HBeAg and those negative with HBeAg. Conclusions Subtypes Ba and C2 are predominant in HBV-infected patients in Hefei. Genotype C may be associated with the development of liver cirrhosis and hepatocellular carcinoma.
