Protective effect of myeloid-derived suppressor cells in mice with sepsis
10.3969/j.issn.1006-5725.2014.11.003
- VernacularTitle:髓源性抑制细胞对脓毒症小鼠的保护作用
- Author:
Xiaoguang HU
;
Li TONG
;
Yongjun LIU
;
Lu CAO
;
Yanping ZHU
;
Xiangdong GUAN
;
Changjie CAI
- Publication Type:Journal Article
- Keywords:
Sepsis;
Myeloid-derived suppressor cells;
Inflammation
- From:
The Journal of Practical Medicine
2014;(11):1690-1692
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether myeloid-derived suppressor cells (MDSCs) have a protective effect in septic mice. Methods The model of caecal ligation and puncture (CLP) was performed to induce polymicrobial sepsis in mice. The changes of MDSCs in spleens at different times after operation were studied. In order to observe the influence of MDSCs on the inflammatory factors and survival of septic mice, MDSCs were injected into the peritoneal cavities of mice after CLP. Results MDSCs accumulated in spleens of septic mice progressively. MDSCs could increase anti-inflammatory cytokine production, decrease the level of inflammatory factors, and improve the survival rate of mice with sepsis. Conclusion MDSCs can attenuate the inflammation and improve the survival rate of mice with sepsis, suggesting that intraperitoneal injection of MDSCs may provide a new direction for the treatment of sepsis.
