Outcomes of percutaneous coronary intervention combined with edaravone injection in treating ST-segment elevation acute myocardial infarction
10.3969/j.issn.1006-5725.2014.11.015
- VernacularTitle:经皮冠状动脉介入治疗联合依达拉奉治疗ST段抬高型急性心肌梗死再灌注损伤的临床观察
- Author:
Bangguo KANG
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Percutaneous coronary intervention;
Edaravone
- From:
The Journal of Practical Medicine
2014;(11):1729-1731
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy and clinical security of percutaneous coronary intervention combined with edaravone injection in treating ST-segment elevation acute myocardial infarction. Methods Group A was treated with conventional percutaneous coronary intervention plus edaravone injection , while group B was treated only with conventional percutaneous coronary intervention. Outcomes were compared between these two groups after the intervention. Results The two groups were successfully operated by percutaneous coronary intervention treatment. Thrombolysis in myocardial infarction,TIMI myocardial perfusion grade and ST-segment recovery after operation had no significant difference. After 48 h treatment, MDA in serum of group A was (3.16 ± 0.12)mol/L. Serum MDA content in group B, was (4.38 ± 0.13)mol/L. The difference was statistically significant (P<0.05). In addition, 7 d cardiac function indexes and cardiac arrhythmia rate were lower than those in group B (P < 0.05). Conclusions The combination use of percutaneous coronary intervention and edaravone can effectively improve heart function in patients shortly in the treatment of ST-segment elevation acute myocardial infarction.Hhowever, the further studies are still needed to evaluate the long term efficacy.
