The relationship between vascular endothelial growth factor, endostatin and type 2 diabetic nephropathy
10.3969/j.issn.1006-5725.2014.11.025
- VernacularTitle:血管内皮生长因子和内皮抑素与2型糖尿病肾病的关系
- Author:
Hui LI
;
Yi QIAN
;
Yaoming XUE
;
Fang GAO
;
Qian ZHANG
- Publication Type:Journal Article
- Keywords:
Diabetes,type 2;
Nephropathy;
Vascular endothelial growth factor;
Endostatin
- From:
The Journal of Practical Medicine
2014;(11):1764-1767
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the possible association between vascular endothelial growth factor (VEGF), endostatin (ES) and type 2 diabetic nephropathy. Methods The level of serum VEGF and ES were measured by ELISA in eighty type 2 diabetic patients including thirty subjects without diabetic nephropathy , twenty with microalbuminuria and thirty with macroalbuminuria, and the correlation was analyzed. Results The level of serum VEGF and ES in patients with macroalbuminuria were both significantly higher than that of patients with and without microalbuminuria (P < 0.05). The level of serum VEGF and ES in patients with microalbuminuria were significantly higher than that of patients without diabetic nephropathy (P<0.05). Both VEGF and ES level were positively correlated with the level of microalbuminuria (mAlb) (r=0.226, P<0.01; r=0.491, P<0.01), and negatively correlated with the level of estimated glomerular filtration rate (eGFR) (r=-0.237, P<0.05;r=-0.620, P<0.01). There was a significantly positive correlation between VEGF and ES in patients with microalbuminuria and macroalbuminuria (r1=0.633, P1<0.01; r2=0.532, P2<0.05). However, there was no correlation between VEGF and ES in patients without diabetic nephropathy (r3=0.175, P3>0.05). Conclusion The levels of VEGF and ES in type 2 diabetic nephropathy had varying degree of increasing in different diabetic nephropathy stage , and closely related to mAlb and eGFR. Disequilibrium of VEGF and ES may speed up the progression of diabetic nephropathy.
