Comparison of different susceptibility testing methods of tigecycline against imipenem-resistant Acinetobacter baumannii

VernacularTitle:不同药敏方法检测替加环素对耐亚胺培南鲍曼不动杆菌敏感性的比较
Author: Jingjing CHEN ; Liyan ZHANG ; Zhengxian CHEN
Publication Type:Journal Article
Keywords: Acinetobacter baumannii; Microbial sensitivity tests; Tigecycline
From: The Journal of Practical Medicine 2014;(12):1990-1992
CountryChina
Language:Chinese
Abstract: Objective To evaluate the susceptibilities of different testing methods of tigecycline against IRAB. Methods MIC and inhibitory zone diameters of 32 strains of IRAB for tigecyclinc were determined by different testing methods.Data were analyzed by comparing the results from each method to those produced by the reference macro broth dilution method. Results The rates of sensitivity intermediate resistance detected by macro broth dilution method , agardilution , MTS and Vitek-2 instrument , disk diffusion method were as follows , 34.375%, 65.625%, 0%, 3.125%, 81.25%, 15.625%, 75%, 25%, 0%, 78.125%, 21.875%, 0%, 3.125%, 81.25%, 15.625%. Compared with macro broth dilution method ,the key major error rate of other methods was 0% by FDA breakpoints , but the CA and EA rates were less than 90%. Conclusions Tigecycline has good activity against the IRAB, with significant difference in susceptible rate among the different methods.