Correlation research between single nucleotide polymorphism of methylenetetrahydrofolate reductase and Alzheimer′s disease in South China Han people
10.3969/j.issn.1006-5725.2014.11.013
- VernacularTitle:MTHFR基因单核苷酸多态性与中国南方汉族阿尔茨海默病的相关性分析
- Author:
Juan ZHAO
;
Zhengyan ZHOU
;
Chaoqun CAI
;
Huaxu YU
;
Yi ZHOU
- Publication Type:Journal Article
- Keywords:
Methylenetetrahyfrofolate reductase;
Single nucleotide polymorphism;
Alzheimer′s disease
- From:
The Journal of Practical Medicine
2014;(11):1722-1724
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between single nucleotide polymorphism (677C→T) of methylenetetrahydrofolate reductase and Alzheimer′s disease(AD) in south China Han people. Methods By applying polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP), MTHFR 677C→T mutation was detected in 45 AD patients and 48 healthy controls. Results The frequency of MTHFR 677C→T mutation of patients showed no significant difference to that of healthy controls (P > 0.05). There is no statistic significance between AD group and controls in C, T gene frequency(P>0.05). But T gene frequency is higher in AD group than in control group. Conclusion MTHFR C 677T is not the pathogenic factor for AD, but could have some effects on AD.
