Screening for Caveolin-3 gene polymorphism in Chinese Han diabetic patients
10.3969/j.issn.1006-5725.2014.11.023
- VernacularTitle:Caveolin-3基因多态性的筛查及其在中国汉族糖尿病患者中的特点
- Author:
Qin HUANG
;
Yiyuan HUANG
;
Yufeng DENG
;
Jing XIAN
;
Wensheng LU
;
Hongqiao WEI
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Caveolin-3;
Gene polymorphism;
PCR-SSCP
- From:
The Journal of Practical Medicine
2014;(11):1757-1759
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the difference of caveolin-3(CAV3) gene polymorphism between normal people and diabetic patients in Chinese Han population. Methods Exon gene polymorphism in 50 normal people and 50 T2DM patients were detected by PCR-SSCP. Results The cumulative incidence rate of electrophoretic variation in T2DM patients was 48%, while cumulative incidence rate of normal people was 7%(P<0.001). It was proved that in the variant bands, there were base variant. Conclusions The variant base number of CAV3 gene in human T2DM samples are significantly more than the normal which can be preliminary detected by PCR-SSCP. It indicates that CAV3 gene polymorphism may be one of the genetic backgrounds for the occurence of Chinese T2DM.
