Analysis of clinical and pathological features of chronic hepatitis B with hepatic steatosis
- VernacularTitle:慢性乙型肝炎合并非酒精性脂肪性肝病临床和病理分析
- Author:
Yaodong ZHANG
;
Raojiang XU
;
Weiquan SONG
- Publication Type:Journal Article
- Keywords:
Hepatitis B,chronic;
Fatty liver;
Liver fibrosis
- From:
Journal of Chinese Physician
2014;(z1):8-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate clinical and pathological features of chronic hepatitis B ( CHB) with nonalcoholic fatty liver disease(NAFLD).Methods The clinical and pathological data of 70cases of CHB and 68 cases of CHB with NAFLD and 42cases of NAFLD were analyzed and compared .Results In this patients with CHB overlapped NAFLD , plasma ALT,AST,GGT con-centrations were higher than that in CHB and NAFLD groups ( P <0.05 , P <0.01 ) , compared with CHB group ,the levels of serum TC,TG,FBS,INS and IRI on patients with CHB overlapped NAFLD were increased ( P <0.05, P <0.01), Compared to patients B groups, serum hepatitis B virus DNA titer in patients with steatosis was significantly lower ( P <0.05) and reduced sharply with the increasea degree of hepatic steatosis ( P <0.05 ) .hepatic inflammation grade and fibrosis stage between CHB patients with and with-out steatosis ( P >0.05 ) .Conclusions The reverse association of hepatitis B virus titer with the degree of hepatic steatosis needs further investigation .Hepatic steatosis is associated with metabolic factors than virus factors .The existence of hepatic fatty degeneration dose not exacerbate liver inflammation or fibrosis .
