Renal tubular acidosis inducede ffects in the process of renal interstitialfibrosis

VernacularTitle:肾小管酸中毒在致肾间质纤维化中的作用
Author: Xiumeng CHEN ; Zhuoyin LIANG
Publication Type:Journal Article
Keywords: Renal tubular acidosis; Renal interstitial fibrosis (RIF); Intgrin-linked kinase (ILK); Obstructive nephropathy
From: Journal of Chinese Physician 2014;(z1):24-26
CountryChina
Language:Chinese
Abstract: Objective Study of renal tubular acidosis induced effects in the process of renal interstitial fibrosis .Methods Twenty rats in the sham operation group , the experimental group UUO40 only, Screening of renal tubular acidosis group , After opera-tion 7, 14, 21, 28 days, the rats were killed in batches, kidney function , organization and determination of integrin linked kinase in renal tissue immunohistochemistry and Western blot ( ILK ) expression were detected .Results UUO +RTA group than in UUO group, under the light microscope , inflammatory cell infiltration and interstitial fibrosis were more serious; Protein expression in control group only a small amount of ILK protein ,Almost no FN protein deposition ,Deposition of UUO expression of group ILK and FN proteins increased,and UUO+RTA group was more than UUO group .Conclusions In obstructive nephropathy , renal tubular acidosis can be deposited and expression of FN and up -regulation of ILK protein .