Screening of the Different Concentrations of Ethanol Extracts from Smilax China for Its Antiinflammatory Activity
10.3870/yydb.2014.07.005
- VernacularTitle:菝葜不同浓度乙醇提取物的抗炎活性筛选
- Author:
Yanqin LUO
;
Yun MA
;
Luyao SONG
;
Fei QIN
;
Yinzhou FAN
;
Lianbing HOU
- Publication Type:Journal Article
- Keywords:
Smilax China;
Ethanol extracts;
Edema,ear;
Granuloma
- From:
Herald of Medicine
2014;(7):858-862
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of the different concentrations of ethanol extracts of Smilax China on ear edema in mice and granuloma in rats,and to provide an evidence for optimizing the extraction process. Methods Effects of different concentrations of ethanol extracts of Smilax China on the xylene-induced ear edema in mice and the cotton ball-induced granuloma hyperplasia in rats were tested . Results Compared with the model controls,70% ethanol extracts of Smilax China at high,medium and low doses significantly inhibited ear edema in mice (t=2. 58,P<0. 05;t=2. 28,P<0. 05;t=2. 17,P<0. 05) and reduced the granuloma hyperplasia in rats(t=5. 28,P<0. 01;t=5. 24,P<0. 01;t=5. 17,P<0. 01). Conclusion The 70% ethanol extracts of Smilax China at three doses present the most active antiinflammatory effect,confirmed in both mice ear edema and rats granuloma models.
