Effects of Compound Xueshuantong Capsule Against Cerebral Ischemia and Hypoxia in Mice
10.3870/yydb.2014.07.007
- VernacularTitle:复方血栓通胶囊改善小鼠脑缺血与耐缺氧作用
- Author:
Mengru SHAO
;
Si WEN
;
Jing LIU
;
Houxi ZHU
- Publication Type:Journal Article
- Keywords:
Xueshuantong capsule,compound;
Ischemia,cerebral;
Tolerating absence of oxygen;
Mice
- From:
Herald of Medicine
2014;(7):866-868
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of the compound xueshuantong capsule ( FXC) against cerebral ischemia and hypoxia in mice. Methods KM mice were randomly divided into the sham operation group ( normal control group) , model control group, positive control group and FXC at high-,medium-and low-dose(0. 75,1. 50,and 2. 25 g·kg-1 ) groups. After intragastric administration for 7consecutive days,cerebral ischemia model was established by unilateral carotid arteries ligation. The cerebral water content and stroke index were recorded. The viability of the mice was determined by testing atmospheric hypoxia,sodium nitrite poisoning and acute cerebral anoxia. Results FXC decreased water content and stroke index of the mice suffered from unilateral carotid artery ligation dose-dependently (P<0. 05,P<0. 01) . It also prolonged the survival of mice by tolerating absence of oxygen,sodium nitrite poisoning and acute cerebral anoxia (P<0. 05,P<0. 01). Conclusion FXC has a protective effect on cerebral ischemia and hypoxia in mice.
