Studies on the Chronic Toxicity of Zukamu Granules in Rats

VernacularTitle:祖卡木颗粒大鼠灌胃长期毒性研究
Author: Qin DOU ; Ming YAN ; Keao LI ; Zhijian LI ; Rapkat HAXIMJAN ; Zhihong JI
Publication Type:Journal Article
Keywords: Zukamu granula; Rat; Toxicity,chronic
From: Herald of Medicine 2014;(7):869-873
CountryChina
Language:Chinese
Abstract: Objective To study the chronic toxicology of Zukamu granules in rats. Methods A total of 120 healthy SD rats ( male  female = 1 1 ) were randomly divided into the control, low ( 0. 72 g · kg-1 · d-1 ), middle (1.43 g·kg-1·d-1),and high (2.86 g·kg-1·d-1) doses of Zukamu granules. The drug was given orally,once daily for a month,and the controls were given with sodium carboxymethyl cellulose. A 2-week recovery period was allowed after the drug withdrawal. Results Three rats in the high dose group developed diarrhea and loose stools for one day. Compared with the control group,the white blood cells ( WBC) ,red blood cells ( RBC) ,hemoglobin ( HGB) ,hematocrit ( HCT) and chlorine ( Cl-) in the high dose group increased. Prothrombin time ( PT ) , blood urea nitrogen ( BUN ) , alanine aminotransferase ( ALT ) , cholesterol(CHO),and aspartate aminotransferase (AST) decreased markededly in the low,middle and high dose group. No obvious change was found in histopathological examination. Conclusion No obvious toxicity was observed in SD rats treated with Zukamu granules at 1. 4g·kg-1·d-1(equivalently to crude drug of 20. 8 g·kg-1·d-1) given orally for one month.