Efficacy of Trimebutine Combined with Mosapride on Functional Dyspepsia
10.3870/yydb.2014.07.013
- VernacularTitle:曲美布汀联合莫沙必利治疗功能性消化不良113例
- Author:
Yingbin HU
;
Jueping FENG
;
Na PENG
;
Fei LV
;
Qiuxia GUO
- Publication Type:Journal Article
- Keywords:
Trimebutine;
Mosapride;
Dyspepsia,functional
- From:
Herald of Medicine
2014;(7):887-890
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of trimebutine combined with mosapride on functional dyspepsia. Methods Patients with functional dyspepsia were randomly divided into three clinical groups. Group A (n=116) received 0.2 g trimebutine after meal,group the drug combination B (n=116) received 5 mg mosapride before meal,and the drug combination group (n=115) received 0. 2 g trimebutine after meal plus 5 mg mosapride before meal. All medications were taken orally three times daily for 4 weeks. Improvement in clinical symptoms and adverse reactions in each group were evaluated at the end of study. Results A total of 339 patients among 347 enrollees completed the treatment and follow-up. The clinical efficacy on postprandial fullness, early satiation, epigastric pain, epigastric burning, upper abdominal bloating and nausea were 88. 4%,76. 9%,72. 9%,61. 8%,86. 7% and 81. 7%,respectively in the drug combination group after 4-week treatment,which were superior to those in group A or B (P<0. 05) except for epigastric burning. The total effective rate of the drug combination group was 78. 8%,significantly higher than the other two groups (P<0. 05). The total incidence of side effects in the drug combination group was 1. 8%,similar to that of group A and B (1. 8% and 0. 9%,respectively, P =0. 776). Conclusion Trimebutine combined with mosapride is safe and effective for improving symptoms in functional dyspepsia.
