New progresses of research methods and achievements on persisters
- VernacularTitle:持留菌研究方法的新进展
- Author:
Bei JIANG
;
Shu LI
;
Xiaomei HU
- Publication Type:Journal Article
- Keywords:
Persister cells;
Infection;
Persistence mechanisms
- From:
Journal of Medical Postgraduates
2014;(6):665-668
- CountryChina
- Language:Chinese
-
Abstract:
Persister cells are dormant or slowly grown variations in microbial populations .They are highly tolerant to antibiot-ics but the tolerance are not inherited as the genetic resistance , when persisters are inoculated to fresh medium , most bacteria are still susceptive to antibiotic , while only a small fractiont become persisters again .Persisters are believed to be closely related to clinic bio-film forming and the recurrence and recalcitrance of chronic infections .Different persisters have been found in Escherichia coli , Pseud-omonas aeruginosa , Staphyococcus aureus , Mycobacterium tuberculosis , Candida albicans and so on , and a few mechanisms about per-sisters formation have been studied .This article reviews the current progresses of research methods and achievements on persisters from different levels .
