The correlation research progress between leptin and senile osteoporosis
- VernacularTitle:老年性骨质疏松和瘦素的相关性研究进展
- Author:
Xifeng SUN
;
Jie LIANG
- Publication Type:Journal Article
- Keywords:
Senile osteoporosis;
Leptin;
Bone mass;
Bone metabolism;
Leptin resistance
- From:
Journal of Medical Postgraduates
2014;(6):669-672
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis is a kind of systemic metabolic bone diseases ,characterized by bone loss , bone subtle structural dam-age.Leptin is a peptide hormone which secreted by fat cells , that has both positive and negative effects to the bone , and plays a role of regulating on bone metabolism .In vitro, Leptin can regulate proliferation of osteoblast and inhibit reabsorption of osteoblasts depend on osteoclast.In vivo, Leptin can inhibit the synthesis of serotonin in the brain stem and increase the sympathetic nerve signals output by the hypothalamus to the bone , it mainly has a negative effect .But clinical trials about the correlation between Leptin and senile oste-oporosis, the role of Leptin in the central nervous system and peripheral tissue problems are still unclear .In this paper, we will make a comprehensive overview about the latest research progress in the correlation between leptin and senile osteoporosis .
