In vitro Characteristics and Hemostatic Effect of O -carboxymethyl Chitosan Multi-hemostatic Sponge
10.3870/yydb.2014.07.003
- VernacularTitle:O-羧甲基壳聚糖复凝止血海绵的体外表征与止血作用
- Author:
Hui LIU
;
Qinghe ZOU
;
Di WU
- Publication Type:Journal Article
- Keywords:
O-carboxymethyl chitosan;
Multi-hemostatic sponge;
Characteristics in vitro;
Hemostasis function
- From:
Herald of Medicine
2014;(7):850-852
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics in vitro and hemostatic function of O -carboxymethyl chitosan multi-hemostatic sponge. Methods Freeze-drying technology was applied on preparation of O -carboxymethyl chitosan hemostatic sponge. The physicochemical properties of the self-produced multi-hemostatic sponge were observed for its appearance, porosity rate,water absorption,and density. The hemostatic effect was compared between the self-produced hemostatic sponge and commercially available absorbable gelatin sponge in rabbit models with ear venous and arterial injuries. Results The self-produced hemostatic sponge was off-white and full of pores with good tenacity and even net texture. Its porosity ratio, water absorption rate, and density were 67. 23%,38. 77%,and 0. 043 4 g·(cm3)-1,respectively. The bleeding time volume were significantly lower from the self-produced sponge than that from the commercially available gelatin sponge. No secondary re-bleeding was observed. Conclusion The self-produced O -carboxymethyl chitosan multi-hemostatic sponge displays stable physicochemical characteristics and reliable hemostatic effect.
