Application of RBF and RSM in Optimizing the Processing Conditions of Manchurian Dutchmanspipe Stem with Alkali
10.3870/yydb.2014.07.021
- VernacularTitle:优选关木通碱制工艺中径向基函数与响应曲面法的应用
- Author:
Min HE
;
Jing ZHANG
;
Lin YANG
- Publication Type:Journal Article
- Keywords:
Response surface methodology;
Radial basis function;
Aristolochia manshuriensis;
Optimization design
- From:
Herald of Medicine
2014;(7):914-916
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the processing conditions of Manchuiran Dutchmanspipe Stem with alkali. Methods The combination of radial basis function ( RBF) and response surface methodology ( RSM) was used to investigate the influence of NaHCO3 , concentration, duration and cycles of processing on the content of aristolochic acid. Results The optimal process was achieved when Manchuiran Dutchmanspipe Stem was soaked for 3 cycles in 0. 05 mol·L-1 NaHCO3 solution, for 24 hours in each cycle. The removal rate of total aristolochic acid approached to 83. 74%. Conclusion The combination of RBF and RSM provided a new method and good guidance for further toxicity attenuation for Manchuiran Dutchmanspipe Stem.
