GLU4-may increase insulin sensitivity in type 2 diabetic rats

VernacularTitle:GLU-4蛋白表达增加与糖尿病大鼠胰岛素敏感性升高有关
Author: Cuijun PANG ; Yumei HE ; Qiuling CHEN ; Yuling HE ; Hailin PAN ; Changqing XIAO
Publication Type:Journal Article
Keywords: Glucose transporter type 4; Diabetes mellitus,type 2; Insulin; Rats,Sprague-Dawley
From: Journal of Chinese Physician 2014;(6):724-727
CountryChina
Language:Chinese
Abstract: Objective To investigate effect of berberine on fasting glucose , fasting serum insulin, islet morphology, and ex-pression of glucose transporter 4 (GLU-4) of islet in type 2 diabetes mellitus (T2DM) rats.The present study aimed to evaluate the ually, especially for high-dose group ( P <0.01).⑷Compared with normal group , INS of diabetic control group was significantly de-creased ( P <0.05), INS of low-dose, middle-dose, and high-dose groups were all increased gradually , especially for high-dose group ( P <0.01 ) .Conclusions Berberine has the effects of antidiabetes via ameliorate insulin sensitivity , and promotes GLUT-4 protein expression .