Comparison of Allergic Rhinitic Models Induced by Various Allergens
- VernacularTitle:不同致敏原诱发过敏性鼻炎模型的比较
- Author:
Peiliang DONG
;
Xin YIN
;
Tianyu ZHANG
;
Na QU
;
Hua HAN
- Publication Type:Journal Article
- Keywords:
Allergic rhinitis;
Models;
Allergen
- From:
China Pharmacist
2014;(2):196-198
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the models of guinea pig allergic rhinitis induced by different allergens. Methods: Ovalbumin (OVA), 2,4-tolylene diisocyanate (TDI) and alternariaalternata was respectively used as the allergens to establish the model of guinea pigs allergic rhinitis. The conformity of the models and human allergic rhinitis was studied through the behavioral indices, such as the times of nose itches, nasal discharge flow, histological properties and serum HA and IgE indices. Results:The times of sneezing and scratching nose, serum HA and IgE in OVA group was significantly different from those in the control group (P<0. 001 or P<0. 01). Conclusion:The models of allergic rhinitis induced by OVA are the same as allergic rhinitis in typical symptoms and pathological changes.
