Research on Stability and Bio-safety of Warming Moxibustion Gel-unguentum
- VernacularTitle:温灸凝胶膏剂的稳定性及生物安全性考察
- Author:
Ying WU
;
Yuting YIN
;
Yirou QIAN
;
Zhenglin ZHU
- Publication Type:Journal Article
- Keywords:
Warming moxibustion gel-unguentums;
Stability;
Cell toxicity test;
Sensitization test;
Irritation test
- From:
China Pharmacist
2014;(2):207-209
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the stability and bio-safety of warming moxibustion gel-unguentums( WMG) . Methods: With the commercially available package and at 40℃ ± 2℃, RH (75% ± 5%) for six months,the stability of WMG was inspected. Guinea pig skin sensitization test, rabbit skin irritation test and cell toxicity test were used to investigate the safety. Results:Compared to the results of 0 month, there was no difference in the sample character, containing paste percentage, adhesion, shape, weight difference and all theindices in TLC identification. Cell toxicity test showed that WMG had slight cytotoxicity. Guinea pig skin sensitization test and rabbit skin irritation test indicated that the grade of skin reaction was zero and the primary stimulus index of skin tissues was also zero. Conclusion:The quality of WMG is stable and the production preparation technology is feasible. Moreover, it is safe in transder-mal administration.
