Content Determination of Valacyclovir Hydrochloride Capsules by HPLC
- VernacularTitle:HPLC法测定盐酸伐昔洛韦胶囊含量
- Author:
Binbin PAN
- Publication Type:Journal Article
- Keywords:
Valacyclovir hydrochloride;
Capsules;
HPLC;
Content determination
- From:
China Pharmacist
2014;(2):238-240
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To develop an HPLC method for the determination of valacyclovir hydrochloride capsules. Methods: An Inertsil ODS (250 mm × 4. 6 mm,5μm) column was employed with methanol-0. 02 mol·L-1 potassium dihydrogen phosphate solution (20∶80) as the mobile phase, the flow rate was 1. 0 ml·min-1, the detection wavelength was at 251 nm, the column temperature was 30℃,and the sample size was 20μl. Results:The linear range of valacyclovir hydrochloride was 2-40μg·ml-1 , the correlation coeffi-cient was 0. 999 9 and the average recovery was 99. 8%(RSD=0. 16%,n=9). Conclusion:The analytical method is simple, accu-rate and special, which can be used in the content determination and quality control of valacyclovir hydrochloride capsules.
