Sodium Deoxyribonucleotide Intervention with Bone Marrow Suppression and Liver Injury Induced by Chemotherapy in Solid Tumor:a Randomized Clinical Trial
- VernacularTitle:脱氧核苷酸钠干预实体瘤化疗所致骨髓抑制及肝损伤临床观察
- Author:
Shangxian LIU
;
Yanyu SU
;
Zhenxia LU
;
Butong SUN
- Publication Type:Journal Article
- Keywords:
Deoxyribonucleotide;
Bone marrow suppression;
Live injury
- From:
China Pharmacist
2014;(2):257-259
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of deoxyribonucleotide in intervention with solid tumor. Methods:A exper-imental study and randomized clinical trial were conducted. Experimental study part: MTT assay and S-180 sarcoma method were launched to observe whether the deoxyribonucleotide would affect the tumor growth. Clinical study part:86 patients of lung cancer, gastric cancer, colorectal cancer, liver cancer were divided into control group(n=43) and treatment group (n=43). Both group were given routine therapy,and the treatment group were given deoxyribonucleotide at the same time. Bone marrow suppression and live function were assessed after chemotherapy. Results:Chemotherapy Clinical effect did not improved in Deoxyribonucleotide group (47. 5% vs 44. 9%, P>0. 05), however, theⅢ-Ⅳbone,NKcellswere improved by deoxyribonucleotide (P<0. 05). What is more, the live injury of treat-ment group were less than the control group. Conclusion:Deoxyribonucleotide can decrese the occurace rate of live injury and bone mar-row suppression.
