Curative Effect of Methylprednisolone Combined with Conventional Treatment on Severe Hand-foot-mouth Disease in Children
- VernacularTitle:甲泼尼龙联合常规治疗儿童重型手足口病观察
- Author:
Xiuchun HUANG
;
Xuan CHEN
;
Xuerong WU
- Publication Type:Journal Article
- Keywords:
Methylpreclnisolone;
Corticosteroid;
Hand-foot-mouth disease;
Efficacy
- From:
China Pharmacist
2014;(2):275-276
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical effect of glucocorticoid methylprednisolone combined with the conventional treatment on severe hand-foot-mouth disease ( HFMD) in children. Methods:One hundred and twenty children with severe HFMD from our hos-pital were randomly divided into the hormone group and non-hormone group with 60 cases each. The non-hormone group was treated with western routine therapy, and the hormone group was treated with glucocorticoid methylprednisolone 2mg·kg-1 ·d-1 additionally. The changes in such symptoms as fever, rash, surprised and chatter, drowsiness and shock were recorded in all cases. The disappear-ance time of febrile, shock and herpes and hospital stay were compared between the two groups. Results:The clinical effect of the hor-mone group was better than the non-hormone group;it could shorten the disappearance time of febrile, shock, herpes and pharyngeal buccal redness (P<0. 05), while showed no effect on the hospital stay. Conclusion:Glucocorticoid combined with the routine thera-py in the treatment of severe HFMD in infants exhibits better clinical effect.
