Determination of Residual Organic Solvents in Nimodipine Liposomes by Headspace Gas Chromatography
- VernacularTitle:气相顶空色谱法测定尼莫地平脂质体中有机溶剂残留
- Author:
Li XIANG
;
Yujia ZHANG
;
Shaohua CHENG
;
Xiuli ZHANG
;
Mengmeng LIU
;
Xiaqing FANG
;
Lulu WANG
;
Wensheng ZHENG
- Publication Type:Journal Article
- Keywords:
Nimodipine liposomes;
Headspace GC;
Organic Solvent;
Residual
- From:
China Pharmacist
2014;(2):227-229
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a method for determining three residual organic solvents in nimodipine liposomes. Methods:The samples were injected into a DB-624 capillary column (30 m × 0. 32 nm,1. 8 μm) by a headspace sampler and analyzed with an FID detector, the carrier gas was nitrogen, the injector temperature was 250℃, and the detector temperature was 250℃. The column temperature was programmed raised. Results:Three residual solvents, namely ethanol, acetone and acetic ether were completely sepa-rated. There was a good linearity within the experimental concentration range. The average recovery was 98. 9%,98. 5% and 99. 4%(RSD=0. 32%,1. 12%,0. 76%,n=9), respectively. The detection limits was 0. 20, 0. 18 and 0. 22μg·ml-1, respectively . Con-clusion:The method is rapid, sensitive and accurate. It can be used in the determination of residual organic solvents in nimodipine li-posomes.
