Determination of Pantoprazole Sodium for Injection by High Performance Capillary Electrophoresis
- VernacularTitle:高效毛细管电泳法快速测定注射用泮托拉唑钠的含量
- Author:
Ziyu SONG
;
Dazhong DING
;
Chengzhang LUAN
- Publication Type:Journal Article
- Keywords:
Pantoprazole sodium;
High performance capillary electrophoresis;
Determination
- From:
China Pharmacist
2014;(2):240-242
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a method for the content determination of pantoprazole sodium for injection by high performance capillary electrophoresis. Methods:The determination was performed on an uncoated elastic quartz capillary column, the running buff-er was 0. 01 mol·L-1 potassium dihydrogen phosphate buffer, the running voltage was 25kV,the column temperature was 25℃ and the detection wavelength was 289 nm. Results:The linear range was good within the concentration range of 20. 05-200. 51 μg·ml-1(r=0. 999 6). The average recovery was 99. 03%(RSD=0. 86%, n=9). Conclusion:The method is simple, sensitive and reproduci-ble, and can be used in the determination of pantoprazole sodium for injection.
