The correlation between 1405 V polymorphism in CETP gene and therapeutic effect of simvastatin in dyslipidemia patients
- VernacularTitle:胆固醇酯转运蛋白I405 V多态位点与辛伐他汀对血脂异常患者调脂疗效的关联性
- Author:
Fengqin SHOU
;
Yi JIN
;
Xiaoying YANG
- Publication Type:Journal Article
- Keywords:
single nucleotide polymorphism;
simvastatin;
cholesteryl ester transfer protein;
total cholesterol;
high density lipoprotein cholesterol
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(3):48-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between I405 single nucleotide polymorphism in CETP gene and the therapeutic effect of simvastatin in dyslipidemia patients.Methods Genotype information of I405V in CETP gene was detected by SNaPshot TM primer extension assay in 375 dyslipidemia patients.Blood lipid profiles before and 6 weeks after treatment with simvastatin were recorded to analyze the correlation between the therapeutic effect of simvastatin and I405 polymorphism genostype.Results The frequency of I405 V polymorphism was 38.9%in II genotype,48.5% in IV genotype and 12.5%in VV genotype.After being treated with simvastatin for 6 weeks,the serum levels of TC were significantly decreased by 1.21 mmol/L(P <0.01)and HDL-C level was significantly increased by 0.74 mmol/L(P <0.01).Compared with the IV and VV genotypes of I405V polymorphism,the decrease of TC in II genotype patients were 0.26 mmol/L and 0.16 mmol/L more respectively (P<0.01).Meanwhile,the increase of HDL-C was significantly different among three genotypes(P<0.01).HDL-C in II genotype was increased by 0.85 mmol/L,which was 0.19 mmol/L and 0.15 mmol/L more compared with IV genotype and VV genotype,respectively.Conclusion I405V polymorphism in CETP gene is similar with the lipid-regulating effect of simvastatin.The decrease of blood lipid is more significant in patients with II genotype compared with patients with V allele,suggesting that II genotype is the maker which may predict the therapeutic effect of simvastatin in dyslipidemia patients.However,this conclusion still needs further evaluation.
