Inhibitation and radiosensitization effects of hematoporphyrin and radiotherapy on H22 liver cancer mice
- VernacularTitle:喜泊分联合放疗对小鼠H22肝癌移植瘤的抑瘤增敏作用研究
- Author:
Wei LIU
;
Xin XU
;
Yuanyuan LIU
;
Bin LIU
;
Ximei WANG
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
hematoporphyrin;
inhibition rate;
radiosensitization;
apoptosis
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(3):57-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the inhibitation and radiosensitization effect of hematoporphyrin and radiotherapy on H22 liver cancer mice.Methods Mice models of liver cancer were established by subcutaneous injection of H22 cells,tumor-bearing mice were randomly divided into:control group, simple radiotherapy group, small dose hematoporphyrin with radiotherapy group (combined treatment group Ⅰ), middle dose hematoporphyrin with radiotherapy group(combined treatment group Ⅱ),and high dose hematoporphyrin with radiotherapy group (combined treatment group Ⅲ).Tumor volumes,inhibition rate,sensitizing factor,the survival time of mice,pathology,apoptosis and other indicators in five groups were observed after14 days. Results Hematoporphyrin and radiotherapy can inhibit tumor growth in mice,The q values in three combined treatment groups were all above 1.0 at different time points ,and combined treatment groupⅢwas the highest.The three combined treatment groups had higher apoptosis rate than control group and simple radiotherapy group,but the difference within groups were not statistically significant. The survival time in three combined treatment groups were higher than control group,the combined treatment group Ⅱ was the longest and simple radiotherapy group was the shortest.Conclusion Hematoporphyrin has tumor inhibitition and radiation sensitizing effect on H22 liver cancer mice,and the effect was positive correlation with drug dose. Hematoporphyrin combined with radiotherapy can extend the lifespan of mice in H22 liver cancer,its sensitizing mechanism may be association with induction of H22 cell apoptosis.
