Changes of D-Dimer and Immunoglobulin in Children with Mycoplasma Pneumonia and its Significance
- VernacularTitle:支原体肺炎患儿D-二聚体、免疫功能变化及其意义
- Author:
Li HAO
;
Chengzhong ZHENG
- Publication Type:Journal Article
- Keywords:
mycoplasma pneumonia;
T lymphocyte subsets;
D-Dimer;
immunoglobulin
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(3):156-159
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of T-lymphocyte subsets,D-Dimer and immunoglobulin in mycoplasma pneumonia children and its significance.Methods The levels of T lymphocyte subsets (CD3 +、CD4 +、CD8 +、CD4 +/CD8 +)in 50 children with mycoplasma pneumonia (MPP Group)and 50 healthy children were detected by flow cytometry;The levels of D-Dimer were detected by immunoturbidimetry;The levels of serum immunoglobulin were detected by immune turbidimetric method.Results The results of T lymphocyte subsets:Compared with normal control group, CD3 +and CD4 +peripheral blood cells in MPP group were significantly declined(P<0.001)、CD8 +cells were increased slightly,but with no significant difference、CD4 +/CD8 +ratios were decreased slightly.The results of D-Dimer:Compared with normal control group,the levels of D-Dimer in MPP group were significantly escalated(P<0.001).The results of immunoglobulin:IgA and IgMin MPP group were both significantly higher than those of normal group,but IgG was not different from that in normal group.Conclusion Children with mycoplasma pneumonia have immune disorder,which may generate abnormal clotting.Therefore,besides the conventional anti-mycoplasma pneumonia treatment,we need to detect the levels of D-Dimer according to the clinical symptoms and disease progression and strength the regulation and treatment of the immune system.
