Optimizing the preparation of doxycycline hydrochloride sustained release tablet using response surface methodology
- VernacularTitle:响应面法优化盐酸多西环素缓释片处方工艺
- Author:
Baiqi YU
;
Yonglu WANG
;
Haixiang YIN
;
Dong WANG
;
Beibei LV
;
Xueming LI
- Publication Type:Journal Article
- Keywords:
doxycycline hydrochloride;
sustained-release tablets;
response surface methodology;
release in vitro
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(3):165-168
- CountryChina
- Language:Chinese
-
Abstract:
Objective In this article Response Surface Analysis(RSA)was applied to optimize the formulation of doxycycline hydrochloride sustained release tablet.Methods Single factor exploration was used to determine the three factors which have the greatest impact on the release rate.The three factors were the dosage of the HPMC in the total weight of the tablet,the concentration of PVP-K30,and the ratio of lactose to microcrystalline cellulose,respectively.The composite score of the release behaviour was taken as the response value.The dosage of the ingredients were determined by Box-Benhnke design principles and 3 factors and 3 levels.Results The optimized formulation and process are as follows:the dosage of the HPMC in the total weight of the tablet was 30%;the concentration of PVP-K30 was 10%,and the ratio of lactose to microcrystalline cellulose was 13.The release behavior in vitro is ideal.Conclusion The optimized preparation process of doxycycline hydrochloride sustained release tablet is stable,highly efficient and suitable for industrial production.
