Preparation and determination of Wan Tong Yan Kang dripping pills
- VernacularTitle:万通炎康滴丸制备工艺及含量测定
- Author:
Wangpeng SHENG
- Publication Type:Journal Article
- Keywords:
Wan Tong Yan Kang dropping pills;
preparation process;
orthogonal experiment;
high performance liquid chromatography
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(3):174-177
- CountryChina
- Language:Chinese
-
Abstract:
Objective To Prepare and prefer method for the determination Wan Tong Yan Kang dripping pills. Methods Based on the Orthogonal test,the roundness and dissolution time were regarded as the index,the proportion of PEG4000 and PEG6000,the ratio of drug and matrix and material temperature were investigated. The pill weight pass rate (%)was regarded as the index to prepare dropping pills,the distance,dropping speed and temperature were investigated.Established isofraxidin content assay by HPLC. Results The best preparation method for drugs is:PEG4000 PEG6000 is 72,rugs:standard is1:4;the material temperature is 90 ℃;the cooling liquid temperature is 5 ℃;dropping distance is 10cm,dropping speed is 30 d/min. Isofraxidin regression equation is Y=26842X-835,R2 =0.998. Isofraxidin has good linear relationship in the range of concentrations 0.852-4.26 μg/mL. Conclusion The dripping pill preparation method is simple and feasible. Determination method has high sensitivity and good repeatability. The experiment provides a basis for the preparation of dripping pills and establishment of quality standards.
