Incidence and possible reasons for discordant results between positive FDP and negative D-dimer latex assays in clinical specimens.
10.3349/ymj.1999.40.2.107
- Author:
Kyung Soon SONG
1
;
Young Ah KIM
;
Hyun Kyung KIM
;
Quehn PARK
Author Information
1. Department of Clinical Pathology, Yonsei University College of Medicine, Seoul, Korea. kssong@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
FDP;
D-dimer;
discordance;
fibrinogenolysis
- MeSH:
Blood Coagulation Disorders/blood*;
Disseminated Intravascular Coagulation/blood*;
Fibrin Fibrinogen Degradation Products/analysis*;
Human;
Latex Fixation Tests*
- From:Yonsei Medical Journal
1999;40(2):107-111
- CountryRepublic of Korea
- Language:English
-
Abstract:
In general, FDP and D-dimer values have a correlation in clinical conditions associated with disseminated intravascular coagulation(DIC) or coagulation activation. However, there are some patients with discordant results who demonstrate elevated FDP and negative D-dimer results by latex agglutination assays. The incidence and possible reasons for the discordance between FDP and D-dimer results were investigated through simultaneous measurements (n = 763) from clinical patients with suspected DIC or coagulation activation. 24.8% (189/763) of samples with elevated FDP were negative for D-dimer assays by the latex agglutination method. Further detailed analysis on randomly-selected discordant samples (n = 41) revealed that the most common reason for the discordance was the lower sensitivity of the semiquantitative latex agglutination method for D-dimer, compared with quantitative enzyme or other latex immunoassay. The other contributing factors to the discordance were accelerated fibrinogenolysis without secondary fibrinolysis, elevated soluble fibrin monomer and rheumatoid factor.
