The loss of expression of transforming growth factor-beta receptors correlates with the histopathologic tumor grade in bladder transitional cell carcinoma patients.
10.3349/ymj.1999.40.2.118
- Author:
Dong Hyeon LEE
1
;
Seung Choul YANG
;
Sung Joon HONG
;
Byung Ha CHUNG
;
Hyun Jik CHUNG
;
Hideo TOKUNAGA
;
Issac Y KIM
;
Yun S SONG
;
Seth P LERNER
;
Ronald A MORTON
Author Information
1. Scott Department of Urology, Baylor College of Medicine, Houston, Texas, USA.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Bladder transitional cell carcinoma;
TGF-beta receptor;
tumor grade
- MeSH:
Adult;
Aged;
Bladder Neoplasms/pathology*;
Bladder Neoplasms/metabolism*;
Carcinoma, Transitional Cell/pathology*;
Carcinoma, Transitional Cell/metabolism*;
Human;
Middle Age;
Receptors, Transforming Growth Factor beta/metabolism*;
Reference Values
- From:Yonsei Medical Journal
1999;40(2):118-123
- CountryRepublic of Korea
- Language:English
-
Abstract:
Transforming growth factor-beta (TGF-beta), a pleiotropic growth factor, is a potent inhibitor of cellular proliferation in cells of epithelial origin. Recently, it has been suggested that a loss of sensitivity to TGF-beta through a loss of expression of TGF-beta receptors T beta R-I and T beta R-II--is associated with tumor initiation and progression. Therefore, to investigate the relationship between TGF-beta receptors expression and carcinogenesis of bladder TCC, this study examined the expression of T beta R-I and T beta R-II in 46 bladder TCC patients using immunohistochemistry. Since histopathological grade is a widely accepted marker of prognosis, the results were compared in relation to the three grades of bladder TCC. The results demonstrated that the loss of TGF-beta receptors expression is associated with increasing histopathological grades of bladder TCC. Specifically, both T beta R-I and T beta R-II were readily detected in all 10 normal bladder mucosa specimens. Likewise, all 6 specimens of grade I TCC samples expressed high levels of both TGF-beta receptors. However, among grade II TCC samples, T beta R-I and T beta R-II were detected in 78% and 89%, respectively: among grade III TCC samples, T beta R-I and T beta R-II were detected in 45% and 41%, respectively. These results suggested that loss of sensitivity to TGF-beta may play a role in the progression of TCC from low to high grade disease.
