Experimental study on inhibition of autophagy enhancing TRAIL-induced apoptosis in prostate cancer cells
10.3969/j.issn.1671-8348.2014.17.021
- VernacularTitle:抑制自噬增强TRAIL诱导前列腺癌细胞凋亡的实验研究
- Author:
Wenxuan WANG
- Publication Type:Journal Article
- Keywords:
prostate-neoplasms;
autophagy;
tumor-necrosis-factor-related-apoptosis-inducing-ligand;
apoptosis
- From:
Chongqing Medicine
2014;(17):2170-2171
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study whether the TRAIL treating prostate cancer cells can induce autophagy and the role of autoph-agy in it.Methods The expression of autophagy-related protein was detected by Western blot;the toxicity of TRAIL on prostate cancer cells was observed by suppressing autophagy.Results TRAIL could enhance the expression of autophagy-related protein,in-hibiting autophagy could enhance the cytotoxic effect of TRAIL on prostate cancer cells.Conclusion TRAIL can induce the autoph-agy occurrence in prostate cancer and autophagy play a protective role on prostate cancer cells.
