Preliminary voxel-based morphometry analysis of grey matter abnormalities in early stage of bipolar disorder I
10.3969/j.issn.1002-1671.2014.07.002
- VernacularTitle:早期双相情感障碍 I 型脑灰质基于体素形态学初步研究
- Author:
Wenjin ZOU
;
Liping CAO
;
Liqian CUI
;
Xuan LI
;
Guimao HUANG
;
Chongpeng SUN
;
Guohui LAO
;
Jianhua CHEN
;
Yufen OU
;
Wenhao DENG
;
Xinchun LI
- Publication Type:Journal Article
- Keywords:
bipolar disorder;
voxel-based morphometry(VBM);
grey matter;
volume
- From:
Journal of Practical Radiology
2014;(7):1075-1079
- CountryChina
- Language:Chinese
-
Abstract:
Objective To estimate brain grey matter volume changes and location of abnormal brain regions cerebrum in early stage of bipolar disorder I (BD),in order to provided objective basis for diagnosing early stages BD.Methods 1 7 cases of BD with duration less than 2 years and 1 7 normal controls were recruited in this study.The volumetric difference of grey matter between two groups were analyzed by using voxel-based morphometry(VBM)software.Statistical threshold was voxel> 100,P <0.001 (uncor-rected).Results Compared to the normal controls,the grey matter volume of BD patients decreased in the left dorcial anterior cingu-late cortex(ACC),left insular,right sub-genu ACC,left superior temporal cortex,bilateral hippocampus-parahippocampus-amydala and left posterior lobe of cerebellum(P <0.001).Conclusion The grey matter volume of early stage BD patients is decreased,main-ly locating in the bilateral limbic system,the superior temporal gyrus and the cerebellar cortex,which probably is the morphological appearance of pathomechanism in early stages of BD.
