Expression of TSLP and NF-κB in patients with adenomyosis
10.3969/j.issn.1000-484X.2014.07.021
- VernacularTitle:TSLP和NF-κB在子宫腺肌病患者子宫内膜细胞中的表达及意义
- Author:
Ying LIU
;
Yunqing REN
;
Liping XUE
;
Xiaoyan LI
;
Binyu SONG
- Publication Type:Journal Article
- Keywords:
TSLP;
NF-κB p65;
Adenomyosis
- From:
Chinese Journal of Immunology
2014;(7):963-967
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the role of TSLP and NF-κB in the pathogenesis of adenomyosis.Methods:Immunohisto-chemistry was employed to detect the expression of TSLP and NF-κB p65 in the endometrial glandular cell and stromal cell of 35 adeno-myosis patients and 20 hysteromyoma patients as control , and analyze the correlation of the two proteins.The concentration of TSLP was measured by specific ELISA in the serum of healthy subjects besides of the patients with adenomyosis and hysteromyoma .Results:TSLP and NF-κB p65 were both positively expressd in the glandular cells and stromal cells of ectopic and eutopic endometrium of patients with adenomyosis , their expression was significantly higher than that of the control group ( P<0.01 ) , and the expression of TSLP and NF-κB p65 in ectopic endometrium was significantly higher than that in eutopic endometrium ( P<0.01 ).There was positive correlation between TSLP and NF-κB p65 in ectopic endometrium.The concentration of TSLP was higher in the serum of patients with adenomyosis.Conclusion:The TSLP is highly expressed in endometrial glandular and stromal cells of patients with adenomyosis , and there is higher level of TSLP in serum , and there is correlation between the expression of TSLP and NF-κB in ectopic endometrium.
