Umbilical cord mesenchymal stem cell transplantation for treatment of diabetic lower limb vascular disease
10.3969/j.issn.2095-4344.2014.23.011
- VernacularTitle:脐带间充质干细胞移植治疗糖尿病下肢血管病变
- Author:
Xiaoling LI
;
Lvyun ZHU
;
Guangyao SONG
;
Lijing JIA
;
Shaoling YANG
;
Liye HU
- Publication Type:Journal Article
- Keywords:
umbilical cord;
mesenchymal stem celltransplantation;
diabetes mel itus,type 2;
diabetic angiopathies
- From:
Chinese Journal of Tissue Engineering Research
2014;(23):3670-3675
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Compared with bone marrow and autologous peripheral blood stem cells, umbilical cord mesenchymal stem cells are characterized as more primitive, more powerful amplification and lower immunogenicity, no ethical problems, which are more important to the elderly patients with diabetes mel itus. OBJECTIVE:To evaluate the efficacy and safety of umbilical cord mesenchymal stem cells transplantation in the treatment of the elderly patients with diabetic lower limb vascular disease. METHODS:Fifty-six elderly patients with diabetic lower limb vascular disease were randomly divided into observation group and control group. The control group was treated with conventional therapy, while the observation group was treated with umbilical cord mesenchymal stem cells transplantation. RESULTS AND CONCLUSION:Observation group showed a higher efficiency than the control group, with significant difference (P<0.05). After treatment, foot skin temperature, transcutaneous oxygen pressure, and ankle brachial index were al improved in both two groups, and the ankle brachial index showed a better value in the observation group (P<0.05). There were no significant adverse reactions in the two groups. Umbilical cord mesenchymal stem cells transplantation is a simple, safe and effective therapy for the elderly patients with diabetic lower limb vascular disease, with better short-term curative effect.
